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Head and Neck Pathology Jul 2013Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a tumor occurring mostly, but not exclusively, in the base of the tongue. Other locations... (Review)
Review
Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a tumor occurring mostly, but not exclusively, in the base of the tongue. Other locations are minor salivary glands of the oral cavity. Histopathologically, CATMSG resembles papillary carcinoma of the thyroid gland. It usually reveals a solid growth devoid of colloid, and eosinophilic material present in follicular areas is rather pale in contrast to metastatic foci seen in papillary thyroid carcinoma that shows typical deeply eosinophilic colloid with "moth-eaten peripheries" and cystic configuration. In addition, giant multinucleated cells are not observed in CATMSG and psammoma bodies are found only exceptionally. Unlike papillary thyroid carcinoma, CATMSG is composed of hybrid secretory-myoepithelial cells. Most importantly, CATMSG is consistently negative with both thyroglobulin and TTF-1. CATMSG is a distinct tumor entity that also differs from polymorphous low-grade adenocarcinoma by location, cytology, histological architecture, and behavior, with frequent metastases at the time of presentation. Paradoxically, early metastatic disease seen in most cases of CATMSG is associated with an indolent behavior. It makes CATMSG a unique neoplasm among all low-grade salivary gland tumors.
Topics: Adenocarcinoma; Biomarkers, Tumor; Humans; Immunohistochemistry; Salivary Gland Neoplasms; Salivary Glands, Minor; Tongue Neoplasms
PubMed: 23821209
DOI: 10.1007/s12105-013-0457-9 -
Journal of Cancer Research and... Dec 2022Tongue carcinomas account for 25%-40% of intraoral squamous cell carcinomas (OSCCs). Although TNM staging systems is an international standard for cancer reporting,...
BACKGROUND
Tongue carcinomas account for 25%-40% of intraoral squamous cell carcinomas (OSCCs). Although TNM staging systems is an international standard for cancer reporting, prognosis evaluation, and treatment planning, multiple histopathological risk assessment predictors such as tumor thickness (TT), tumor shape, tumor growth pattern, and invasive malignancy grading scoring systems have been studied and should form a basis for prediction and prognostication of such aggressive carcinomas.
AIM
To evaluate and characterize the histomorphological prognostic indicators in OSCCs of tongue and compare it with OSCCs of other anatomic sites within the oral cavity. Furthermore, to elucidate the significance of histopathological indicators in predicting prognosis of tongue squamous cell carcinomas (SCCs).
MATERIALS AND METHODS
Forty SCC cases with 20 each of tongue and 20 from other intraoral sites were retrieved from department archives. Clinical data and staging were obtained for each case. Histomorphological parameters including pattern of invasion (POI), tumor budding (TB), depth of invasion (DOI), TT, lymphocytic host response, tumor-associated tissue eosinophilia (TATE), vascular invasion, perineural invasion (PNI), and muscular invasion were assessed. The results were statistically evaluated.
RESULTS
TB, DOI, and sarcolemmal spread were significant histologic predictors in tongue SCC. Upon correlation of histomorphological parameters with clinical staging, TT, POI, and TATE were observed to be significantly correlated (P ≤ 0.05).
CONCLUSION
The histomorphological risk assessment model may serve as important addition to the existing prognosticators and may be used as a prognostic index to help plan and individualize treatment protocol in cases with aggressive high-risk disease for whom the use of multimodality treatment seems beneficial.
Topics: Humans; Mouth Neoplasms; Carcinoma, Squamous Cell; Squamous Cell Carcinoma of Head and Neck; Tongue Neoplasms; Neoplasm Staging; Prognosis; Head and Neck Neoplasms; Neoplasm Invasiveness; Retrospective Studies
PubMed: 36510969
DOI: 10.4103/jcrt.JCRT_392_20 -
Swiss Dental Journal 2017
Topics: Granular Cell Tumor; Humans; Prognosis; Tongue; Tongue Neoplasms
PubMed: 28480946
DOI: No ID Found -
Journal of Ayub Medical College,... 2018
Topics: Child; Female; Humans; Lymphangioma; Tongue; Tongue Neoplasms
PubMed: 29504356
DOI: No ID Found -
Oral Oncology Oct 2022Surgical removal of squamous cell carcinoma of the tongue (SCCT) with tumour-free margin status (≥5 mm) is essential for loco-regional control. Inadequate margins (<5...
OBJECTIVES
Surgical removal of squamous cell carcinoma of the tongue (SCCT) with tumour-free margin status (≥5 mm) is essential for loco-regional control. Inadequate margins (<5 mm) often indicate adjuvant treatment, which results in increased morbidity. Ultrasound (US)-guided SCCT resection may be a useful technique to achieve more adequate resection margins compared to conventional surgery. This study evaluates the application and accuracy of this technique.
METHODS
Forty patients with SCCT were included in a consecutive US cohort. During surgery, the surgeon aimed for a 10-mm echographic resection margin, while the tumour border and resection plane were captured in one image. Ex-vivo US measurements of the resection specimen determined whether there was a need for an immediate re-resection. The margin status and the administration of adjuvant treatment were compared those of with a consecutive cohort of 96 tongue cancer patients who had undergone conventional surgery. A receiver operating characteristic analysis was done to assess the optimal margin of ex-vivo US measurements to detect histopathologically inadequate margins.
RESULTS
In the US cohort, the frequency of free margin status was higher than in the conventional cohort (55% vs. 16%, p < 0.001), and the frequency of positive margins status (<1 mm) was lower (5% vs. 15%, respectively, p < 0.001). Adjuvant radiotherapy was halved (10% vs. 21%), and the need for re-resection was comparable (10% vs. 9%). A cut-off value of 8 mm for ex-vivo measurements prevented histopathologically inadequate margins in 76%.
CONCLUSION
US-guided SCCT resections improve margin status and reduce the frequency of adjuvant radiotherapy.
Topics: Carcinoma, Squamous Cell; Humans; Margins of Excision; Tongue Neoplasms; Ultrasonography; Ultrasonography, Interventional
PubMed: 35901543
DOI: 10.1016/j.oraloncology.2022.106023 -
Ear, Nose, & Throat Journal Dec 2022Osteomas are rare benign bony tumors located in the tongue area. In most cases, patients presenting with a lingual osteoma are asymptomatic but may complain of the... (Review)
Review
Osteomas are rare benign bony tumors located in the tongue area. In most cases, patients presenting with a lingual osteoma are asymptomatic but may complain of the sensation of having a foreign body. Fewer than 100 cases of lingual osteoma have been reported worldwide. Here, we present 2 cases of tongue base osteoma that were treated with excision under a laryngoscope.
Topics: Humans; Tongue Neoplasms; Osteoma; Tongue Diseases; Tongue
PubMed: 33263414
DOI: 10.1177/0145561320977469 -
Medical Molecular Morphology Mar 2021Immune checkpoint proteins programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important therapeutic targets for head and neck cancer. This...
PURPOSE
Immune checkpoint proteins programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important therapeutic targets for head and neck cancer. This large-scale case study aimed to analyze tongue squamous cell carcinomas (SCCs) and evaluate the correlation between PD-L1 expression and clinical prognosis. So far, this study is the largest case study on PD-L1 expression in tongue SCCs.
METHODS
This is a case-control study that analyzed 121 tongue SCCs. Paraffin-embedded sections and clinical data were obtained retrospectively and immunohistochemistry with PD-L1 was performed.
RESULTS
11.6% contained ≥ 50% of PD-L1-positive cells, 57.1% of these cases had a poor prognosis with nodal metastasis. Among cases of T1/2 primary lesions with nodal metastasis, cases of high PD-L1 expression had a significantly shorter disease-free survival than cases of no PD-L1 expression (p = 0.018). The hazard ratio for high PD-L1 expression was 3.21 (95 per cent CI, 1.26-8.72) compared with no PD-L1 expression after adjusting for other factors.
CONCLUSIONS
These data indicate that PD-L1 upregulation in tongue SCCs is associated with a more advanced stage and shorter disease-free survival. PD-1/PD-L1 inhibitors might hence constitute potential adjuvant therapy for tongue SCCs with PD-L1 upregulation.
Topics: Adult; Aged; Aged, 80 and over; B7-H1 Antigen; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Immunohistochemistry; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck; Tongue; Tongue Neoplasms; Up-Regulation; Young Adult
PubMed: 32699939
DOI: 10.1007/s00795-020-00261-7 -
Kulak Burun Bogaz Ihtisas Dergisi : KBB... 2014Schwannomas are benign, slow growing, solitary and encapsulated neuroectodermal tumors arising from Schwann cells of the nerve sheath. Twenty-five percent of all...
Schwannomas are benign, slow growing, solitary and encapsulated neuroectodermal tumors arising from Schwann cells of the nerve sheath. Twenty-five percent of all extracranial schwannomas are seen in the head and neck region. Intra-oral schwannomas are rare and commonly seen at the tongue base. In this article, a 20-year-old female case with lingual schwannoma as a rare clinical condition and characteristics of the disease were summarized in the lights of the literature.
Topics: Diagnosis, Differential; Female; Humans; Neurilemmoma; Tongue Neoplasms; Young Adult
PubMed: 24835905
DOI: 10.5606/kbbihtisas.2014.79346 -
Journal of Clinical Laboratory Analysis May 2021Currently, many studies have found that RFC4 was up-regulated in various cancers, and related to the progression and development. While the effects of RFC4 in oral...
OBJECTIVE
Currently, many studies have found that RFC4 was up-regulated in various cancers, and related to the progression and development. While the effects of RFC4 in oral tongue squamous cell carcinoma remain unclear, the main purpose of this research is to explore the role of RFC4 in oral tongue squamous cell carcinoma.
METHODS
The expression of RFC4 in various cancers was analyzed in GEPIA database, and the results were further verified by IHC assay. The relationship between RFC4 and several clinical parameters was analyzed; the proliferation was further observed by knockdown RFC4 in vitro. Finally, we constructed related nude mouse models by planting cells subcutaneous of nude mice, and the discrepancy was observed.
RESULTS
Based on GEPIA database, RFC4 was up-regulated in various cancers, including colorectal cancer, breast cancer, prostate cancer, lung cancer, and liver cancer. RFC4 was up-regulated in oral tongue squamous cell carcinoma compared with the normal tissue from GEPIA online database; we further found that the expression of RFC4 was tightly associated with TNM stage (p = 0.005), but not with age, gender, and differentiation (p > 0.05). We further found that the proliferation of oral tongue squamous cell carcinoma was obviously restrained in vitro, and the carcinogenesis was also inhibited in vivo.
CONCLUSIONS
We found that RFC4 was up-regulated and related to the progression of oral tongue squamous cell carcinoma, and knockdown RFC4 could restrain the proliferation and progression. RFC4 might serve a potential biomarker and provide a new treatment strategy for lots of patients with oral tongue squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Mice, Nude; Middle Aged; Neoplasm Staging; Replication Protein C; Tongue Neoplasms; Up-Regulation; Mice
PubMed: 33783864
DOI: 10.1002/jcla.23761 -
Annals of Oncology : Official Journal... Jan 2010The objective of this study is to disprove and dismiss etiological links between human papillomavirus (HPV) and aggressive tongue cancer in young patients. (Review)
Review
BACKGROUND
The objective of this study is to disprove and dismiss etiological links between human papillomavirus (HPV) and aggressive tongue cancer in young patients.
METHODS
Review of available literature with focus on presenting the epidemiological, histological and immunohistochemical arguments against an association between HPV and aggressive glossal neoplasm in younger populations.
CONCLUSION
HPV is not associated with the recent surge in the incidence of biologically aggressive oral cavity cancer in young populations.
Topics: Adult; Humans; Incidence; Papillomavirus Infections; Tongue Neoplasms; Young Adult
PubMed: 19825879
DOI: 10.1093/annonc/mdp380